The following tables are different:
Avalon Hill edition: Political Events Summary
A,B, C or D. Monarch Change 
1. Supply of Colonists Changes 
2. Increased Interest in Overseas Expansion 
3. Decreased Interest in Overseas Expansion 
4. Costly European War Drains Treasury 
5. Civil War at Home 
6. Affluent Middle Class 
7. Graft and Corruption Rife 
8. Guile and Treachery Obtain 'Rutter' for the South Cape 
9. Metallurgical Breathough 
10. Natives Resentful of European Intrusion 
11. Oppressive Colonial Policy 
12. Natives Decimated by Disease 
13. Carib Indians on the Rampage 
14. The Seven Cities of Cibola 
15. El Dorado 
16. Plague in the Colonies 
SPI edition: Political Events Summary
A,B, C or D. Monarch Change 
1. Increased Interest in Overseas Expansion 
2. Metallurgical Breathough 
3. Decreased Interest in Overseas Expansion 
4. Natives Resentful of European Intrusion 
5. Costly European War Drains Treasury 
6. Guile and Treachery Obtain 'Rutter' for the South Cape 
7. Civil War at Home 
8. Oppressive Colonial Policy 
9. Affluent Middle Class 
10. Graft and Corruption Rife 
11. Ready Supply of Colonists 
12. Supply of Colonists Dries Up 
13. Natives Decimated by Disease 
14. The Seven Cities of Cibola 
15. El Dorado 
16. Plague in the Colonies 
17. Carib Indians on Rampage 
Avalon Hill edition: Political Events Table
1st die roll

2nd die roll


1

2

3

4

5

6


1

1

2

6

7

A

A

2

5

1

10

B

B

13

3

8

4

1

B

11

14

4

9

11

C

1

4

15

5

12

C

C

10

1

6

6

D

D

7

6

3

1

SPI edition: Political Events Table
1st die roll

2nd die roll


1

2

3

4

5

6


1

A

1

C

8

9

12

2

7

B

5

2

6

C

3

13

1

B

4

D

10

4

10

16

14

B

12

3

5

D

17

5

11

C

7

6

4

11

3

16

15

A

Avalon Hill edition: Land Attrition
Adjusted Area Attrition Level


Die Roll

1

2

3

4

5

1

C

C

C

C*

C*

2

#

S

S

S

S

3

#

#

CS

CS

CS

4

#

#

#

2CS

2CS

5

#

#

#

#

All

6

#

#

#

#

#

SPI edition: Land Attrition
Adjusted Area Attrition Level


Die Roll

1

2

3

4

5

1

#

#

#

#

#

2

#

#

#

C

C

3

#

#

#

C

C

4

#

#

C

S

CS

5

#

S

S

CS*

2C

6

C

C

C

2C

All

Avalon Hill edition: Naval Attrition
Number of Bounds Travelled


DR

1,2

3

4

5

6

7

8

9+

1

C*

C*

C*

C*

C*

C*

C*

C*

2

#

S

S

S

S

S

S

S

3

#

#

#

CS

CS

CS

CS

CS

4

#

#

#

#

2C

2C

2C

N

5

#

#

#

#

#

N

N

2N

6

#

#

N

N

N

N

2N

All

SPI edition: Naval Attrition
Number of Bounds Travelled


DR

1,2,3

4

5

6

7

8

9

1

#

#

#

#

C

C

CS

2

#

#

#

C*

S*

S*

CS*

3

#

#

C

C

C

CS

2C

4

#

C

C

S

CS

2C

N

5

#

S

S

2C

2C

N

2N

6

C

N

N

N

N

2N*

All

Avalon Hill edition: Naval Combat
Odds (Attacker Sp's to Defender Sp's)


Die roll

13

12

11

21

31

1

Ae*

A3*

A2*

A2/D2

A1/D1

2

Ae*

A2*

A1

A1/D1

D1

3

A3*

A1

A2/D2

A1/D2

D2*

4

A2*

A2/D1

A1/D1

D1

D3*

5

A1

A2/D2

D1

D2*

De*

6

A1/D1

A1/D1

D2*

D3*

De*

SPI edition: Naval Combat
Odds (Attacker Sp's to Defender Sp's)


Die Roll

13

12

11

21

31

41

1

Ae*

A3*

A2*

A2*

A1/D1

A1/D1

2

Ae*

A2*

A1

A1/D1

A1/D2

D1

3

A3*

A1

A2/D1

A1/D2

D1

D2

4

A2*

A2/D1

A1/D1

D1

D2

D3*

5

A1

A1/D1

D2

D2

D3*

D4*

6

A1/D1

A1/D1

D3*

D3*

D4*

De*

Avalon Hill edition: Land Combat
Odds (Attacker to Defender Strength Points)


Die Roll

13

12

11

21

31

41

51

1

A1/2/D1/2

A1/4/D1/2

A1/4/D3/4

D1/2

D3/4*

De*

De*

2

A1/4/D1/4

A1/2/D1/2

A1/4/D1/2

A1/4/D3/4

D1/2

D3/4*

De*

3

A1/2/D1/4

A1/4/D/1/4

A1/2/D1/2

A1/4/D1/2

A1/4/D3/4

D1/2

D3/4*

4

A3/4/D1/4

A1/2/D1/4

A1/4/D1/4

A1/2/D1/2

A1/4/D1/2

A1/4/D3/4

D1/2

5

A1/2

A3/4/D1/4

A1/2/D1/4

A1/4/D1/4

A1/2/D1/2

A1/4/D1/2

A1/4/D3/4

6

A3/4

A1/2

A3/4/D/1/4

A1/2/D/1/4

A1/4/D1/4

A1/2/D1/2

A1/4D1/2

SPI edition: Land Combat
Odds (Attacker to Defender Strength Points)


Die Roll

13

12

11

21

31

41

51

1

A1/2/D1/4

A1/4/D1/2

D1/2*

D3/4*

D3/4*

De

De

2

A3/4/D1/2

A1/2/D1/4

A1/4/D1/2

D1/2

D1/2

D3/4*

De

3

A1/2

A1/4

A1/4/D1/2

A1/4/D1/2

D1/4

D1/2

D3/4*

4

A1/2

A1/2

A1/4/D1/4

A1/4/D1/2

A1/4/D1/2

D1/2

D3/4

5

A3/4*

A1/2*

A1/2/D1/4

A1/2/D1/2

A1/4/D1/2

A1/4/D1/2

D1/2

6

Ae

A3/4

A3/4/D/1/2

A1/2/D/1/4

A1/2/D1/4

A1/4/D1/2

D1/4

Avalon Hill edition: Native Uprising
Soldier Detachments in Area


Die roll

0

1

2,3

4,5

6,7

8+

1

1

1

#

#

#

#

2

2

1

1

#

#

#

3

2

2

1

1

#

#

4

3

2

2

1

1

#

5

3

3

2

2

1

1

6

All

3*

3*

2*

2*

1

SPI edition: Native Uprising
Soldier Detachments in Area


Die roll

0

1

2,3

4,5

6,7

8+

1

1

1

#

#

#

#

2

2

1

1

#

#

#

3

2

2

1

1

#

#

4

3

2

2

1

#

#

5

3*

3*

2

1

#

#

6

All

All

2*

1

1

#

Avalon Hill edition: Gold Table
Area

To Discover

To Deplete

Production

Caribbean

28

25

15

Mainland

25

23

25

Tenochtitlan

#

25

75

Chichen Itza

#

25

40

Cuzco

#

25

100

SPI edition: Gold Table
Area

To Discover

To Deplete

Production

Caribbean

14(1d6)

12(1d6)

15

Mainland

12 (1d6)

2 or 11

25

Tenochtitlan

#

7 or 11

75

Chichen Itza

#

7 or 11

40

Cuzco

#

7 or 11

100

Avalon Hill edition: Rule 2.1
Some islands are marked as 'black land', no settlements allowed:
Cape (5216, 5316, 56112, 5615, 57136, 5814) NB settlement possible on 5715, a Cape hex
Northwest (0131, 02301, 0331, 0431, 0531, 0630)
Saguney (01125, 01179, 02123, 021620, 031920)
Caribbean (2018, 21189, 2217, 2412, 2512, 2611) NB 2512 still has Gold Mine
Maritime (0814)
In the SPI edition the only settelment prohibition is on the Cape hexes, 5715 and 5815 (rule 7.54)
Avalon Hill edition: Rule 2.2
12189 and 121920 are river not lake hexsides. Not in SPI edition
Avalon Hill edition: Rule 6.4.2
One event used for SPI edition events Ready Supply/Supply Dries Up events (rules 6.41, 10 and 11). NB see Political Events Tables above.
Avalon Hill edition: Rule 6.4.15
Seven Cities of Cibola event is ignored turns 1821, not in SPI edition (rule 6.41, 14)
Avalon Hill edition: Rule 6.4.16
El Dorado is given 20 years for completion, not 10 as in SPI edition (rule 6.41, 15).
Avalon Hill edition: Rule 7.2.6
In the event of a friendly port not being available for an Expedition reminaing in the New World, an Expedition may launch a Naval Invasion against a port in the hex it occupies (if any). Not in the SPI edition (rule 7.27).
Avalon Hill edition: Rule 7.4
There is no Movement Point cost to embark/debark. In the SPI edition this costs 3MP per embark/debark (rule 7.32).
Avalon Hill edition: Rule 8.6.2
Captured Explorers/Conquistadors/Missionaries may not be ransomed (as per rule 8.32 in the SPI edition)
Avalon Hill edition: Rule 14.4.4
Ports for Gold shipment in an adjacent area do not have to be 8MPs from a Mine (as per rule 13.44 in the SPI edition). Gold from the Rockies must be shipped from a port on the Pacific coast (not in the SPI edition).
Avalon Hill edition: Optional Rules: B. German Explorers (not in SPI edition)
Alfinger 7/8, Spires 9/10, Federman 9/9, VonHuten 10/11
There are four German explorers. At the beginning of the Planning Segment of Game Turns Seven, Nine and Ten, players may bid for an arriving German Explorer. Each player may bid for every German Explorer. The bidding starts at 1 ducat. Each bid must be higher than the previous bid. A player may bid any number of times. The highest bidder gets the Explorer and deducts from his National Treasury. German Explorers may not be rented by players to other players.
Avalon Hill edition: Optional Rules: C. Secret Treasure City Locations (not in SPI edition)
40,75,75,100,blankx4
Instead of using the three Treasure Cities shown on the map, players may use the eight Treasure City counters instead to add variation to the game. Players place the eight Treasure City counters face down anywhere on the map. When any unit moves into a hex containing a Treasure City counter, the counter is immediately flipped over. If it is a blank it is immediately removed from the game. If it is one of the four Treasure Cities, it is then face up for the rest of the game and can be looted as per the normal game rules.